WP1 - Synthesis of Key Chemicals
A comprehensive library of monomers, oligomers and polymers will be synthesized for use in the three domains of BoneFix, i.e. i) function as a scaffold, ii) biodefradable, and iii) antibacterial. This library will be optimized to provide all of the properties required for BoneFix, from the biodegradation of the bone scaffold, to the high rigidity of the fixation patch, and the anti-bacterial action of the hydrogel coating. The incorporation of allyl and thiol functionalities throughout this library will allow for rapid, on-demand curing of the domains by the surgeon via high energy visible light initiated thiol-ene chemistry.
Lead Participant: Royal Institute of Technology